UDP-N-acetylglucosamine biosynthetic process

Across TCGA patient cohorts, RNA activity of the UDP-N-acetylglucosamine biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GPX8, EPB41L3, and JUP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UDP-N-acetylglucosamine biosynthetic process activity versus GPX8 in BRCA (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GPX8 →	+0.546	+0.030	<.001	<.001	3	7
OV	EPB41L3 →	+0.575	+0.047	.002	.001	3	6
LSCC	JUP →	-0.722	-0.050	<.001	<.001	3	6
BRCA	LIX1L →	+0.350	+0.039	<.001	<.001	3	6
BRCA	CLEC3B →	+0.599	+0.051	<.001	<.001	3	6
BRCA	DCN →	+1.054	+0.048	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006048 vs GPX8 — BRCA

Explore this scatter interactively →