UDP-N-acetylglucosamine biosynthetic process

Across TCGA patient cohorts, RNA activity of the UDP-N-acetylglucosamine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEDAG, RARRES2, and CXCL12, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UDP-N-acetylglucosamine biosynthetic process activity versus MEDAG in OV (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MEDAG →	+1.578	+0.289	<.001	<.001	3	9
BRCA	RARRES2 →	+1.168	+0.175	<.001	<.001	3	8
OV	CXCL12 →	+1.654	+0.304	<.001	<.001	3	8
OV	TYROBP →	+0.851	+0.203	<.001	<.001	3	8
GBM	GFPT2 →	+1.306	+0.236	<.001	<.001	3	8
GBM	EMP3 →	+0.888	+0.249	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006048 vs MEDAG — OV

Explore this scatter interactively →