UDP-N-acetylglucosamine biosynthetic process

Across TCGA cell cohorts, RNA activity of the UDP-N-acetylglucosamine biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNPDA2, GFPT2, and PPFIA2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GNPDA2 grouped by UDP-N-acetylglucosamine biosynthetic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GNPDA2 →	-0.255	-1.502	<.001	<.001	3	8
LUNG_NSCLC_LUSC	GFPT2 →	-0.270	-1.635	.004	<.001	2	8
BLOOD_Myeloma	PPFIA2 →	-0.235	-1.287	.002	.007	3	6
SOFT_TISSUE	SYNC →	-0.227	-1.597	.005	.001	3	6
BREAST	GFPT1 →	-0.176	-1.022	<.001	<.001	3	6
OVARY	UAP1 →	-0.353	-1.349	.005	.003	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GNPDA2 by UDP-N-acetylglucosamine biosynthetic process activity — CNS

Explore this box plot interactively →