UDP-N-acetylglucosamine biosynthetic process

Across TCGA cell cohorts, RNA activity of the UDP-N-acetylglucosamine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTPBP3, FLNB, and HS2ST1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTPBP3 grouped by UDP-N-acetylglucosamine biosynthetic process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GTPBP3 →	-0.944	-1.697	.002	.001	3	5
BONE	FLNB →	+1.832	+1.453	<.001	<.001	3	5
BLOOD_Lymphoma	HS2ST1 →	+2.563	+2.292	<.001	<.001	3	4
BONE	ITGB1 →	+2.174	+1.551	.001	<.001	3	4
BONE	CEMIP2 →	+2.323	+1.453	<.001	<.001	3	4
OVARY	DIPK1A →	+1.286	+1.195	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTPBP3 by UDP-N-acetylglucosamine biosynthetic process activity — BONE

Explore this box plot interactively →