UDP-N-acetylglucosamine biosynthetic process

Across TCGA cell cohorts, RNA activity of the UDP-N-acetylglucosamine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMM44, CREB3L1, and FAT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UDP-N-acetylglucosamine biosynthetic process activity versus TIMM44 in OVARY (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TIMM44 →	+0.730	+1.234	.001	<.001	3	6
OESOPHAGUS	CREB3L1 →	+2.817	+1.325	.003	.003	3	5
OESOPHAGUS	FAT2 →	-3.255	-1.139	.003	.009	3	5
LARGE_INTESTINE	SLC35D1 →	+0.755	+1.061	.001	.007	3	5
LARGE_INTESTINE	DPH5 →	+0.704	+1.381	<.001	<.001	3	5
LARGE_INTESTINE	KRT80 →	-3.648	-1.430	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006048 vs TIMM44 — OVARY

Explore this scatter interactively →