UDP-N-acetylglucosamine metabolic process

Across TCGA patient cohorts, RNA activity of the UDP-N-acetylglucosamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GFPT2, AIF1, and MILR1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UDP-N-acetylglucosamine metabolic process activity versus GFPT2 in OV (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GFPT2 →	+1.061	+0.254	<.001	<.001	3	8
OV	AIF1 →	+0.923	+0.238	.001	.001	3	8
OV	MILR1 →	+1.264	+0.239	<.001	.001	3	8
OV	MEDAG →	+1.534	+0.261	<.001	<.001	3	7
GBM	SRGN →	+1.128	+0.223	<.001	<.001	3	7
OV	SULF1 →	+1.363	+0.216	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006047 vs GFPT2 — OV

Explore this scatter interactively →