UDP-N-acetylglucosamine metabolic process

Across TCGA cell cohorts, RNA activity of the UDP-N-acetylglucosamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTPBP3, P2RY11, and MRPL24, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTPBP3 grouped by UDP-N-acetylglucosamine metabolic process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GTPBP3 →	-1.031	-1.343	<.001	<.001	3	4
PANCREAS	P2RY11 →	-1.329	-1.169	<.001	.002	3	4
LUNG_SCLC	MRPL24 →	-0.793	-1.039	.006	.005	3	4
LIVER	FAAP24 →	+0.916	+1.175	<.001	.004	3	4
OVARY	CEMIP2 →	+1.356	+1.162	.001	<.001	3	4
OVARY	RPL18A →	-0.775	-1.191	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTPBP3 by UDP-N-acetylglucosamine metabolic process activity — BONE

Explore this box plot interactively →