UDP-N-acetylglucosamine metabolic process

Across TCGA cell cohorts, RNA activity of the UDP-N-acetylglucosamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNRC2, DPH5, and PPL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UDP-N-acetylglucosamine metabolic process activity versus PNRC2 in OESOPHAGUS (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PNRC2 →	+0.829	+1.138	.001	.004	3	5
CNS	DPH5 →	+0.649	+1.130	.001	.008	2	6
OVARY	PPL →	-3.153	-1.172	<.001	<.001	3	5
OVARY	SLCO3A1 →	-2.337	-1.677	.002	<.001	3	5
LARGE_INTESTINE	SPA17 →	+0.765	+0.964	<.001	<.001	3	5
OESOPHAGUS	CREB3L1 →	+2.817	+1.316	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006047 vs PNRC2 — OESOPHAGUS

Explore this scatter interactively →