N-acetylglucosamine metabolic process

Across TCGA patient cohorts, RNA activity of the N-acetylglucosamine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRP12, EDC4, and GCN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-acetylglucosamine metabolic process activity versus RRP12 in GBM (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RRP12 →	-0.294	-0.063	<.001	<.001	3	6
GBM	EDC4 →	-0.144	-0.051	<.001	<.001	3	6
PDAC	GCN1 →	-0.233	-0.050	<.001	<.001	3	6
BRCA	TRIM2 →	+0.466	+0.046	.003	<.001	3	6
GBM	RPS5 →	-0.170	-0.052	.006	.005	3	6
BRCA	TMOD1 →	+0.605	+0.030	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006044 vs RRP12 — GBM

Explore this scatter interactively →