N-acetylglucosamine metabolic process

Across TCGA cell cohorts, RNA activity of the N-acetylglucosamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEXB, ZRANB3, and CLN3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-acetylglucosamine metabolic process activity versus HEXB in SOFT_TISSUE (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	HEXB →	+1.727	+2.047	.009	<.001	3	8
LARGE_INTESTINE	ZRANB3 →	-0.825	-0.936	<.001	.001	3	6
BREAST	CLN3 →	+0.993	+1.003	.007	.001	3	5
BLOOD_Lymphoma	FPGT →	+0.661	+0.713	.003	.004	3	5
CNS	CCDC138 →	-0.565	-0.967	.007	<.001	3	5
LUNG_NSCLC_LUAD	TMEM144 →	+0.675	+0.520	.003	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006044 vs HEXB — SOFT_TISSUE

Explore this scatter interactively →