Amino sugar metabolic process

Across TCGA patient cohorts, RNA activity of the Amino sugar metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HEATR1, SMARCA5, and SYNPO, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino sugar metabolic process activity versus HEATR1 in LSCC (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HEATR1 →	-0.286	-0.038	<.001	<.001	3	8
GBM	SMARCA5 →	-0.258	-0.045	<.001	<.001	3	7
BRCA	SYNPO →	+0.338	+0.027	.007	.005	3	7
BRCA	UBR5 →	-0.215	-0.030	<.001	.001	2	8
LUAD	WDR43 →	-0.393	-0.044	<.001	<.001	3	7
BRCA	CSE1L →	-0.293	-0.038	.002	<.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006040 vs HEATR1 — LSCC

Explore this scatter interactively →