Amino sugar metabolic process

Across TCGA patient cohorts, RNA activity of the Amino sugar metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR2A, CSF2RB, and FCGR1A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino sugar metabolic process activity versus FCGR2A in COAD (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FCGR2A →	+0.937	+0.244	<.001	<.001	3	9
BRCA	CSF2RB →	+1.116	+0.150	.003	.006	2	9
UCEC	FCGR1A →	+0.834	+0.191	<.001	<.001	3	8
OV	LILRB3 →	+0.933	+0.275	<.001	<.001	3	8
GBM	CYTH4 →	+0.583	+0.148	<.001	<.001	3	8
GBM	IL2RA →	+1.463	+0.270	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006040 vs FCGR2A — COAD

Explore this scatter interactively →