Amino sugar metabolic process

Across TCGA cell cohorts, RNA activity of the Amino sugar metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OGFR, SLC2A1, and PARD6B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino sugar metabolic process activity versus OGFR in BLOOD_Leukemia (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OGFR →	-0.666	-1.145	<.001	<.001	3	5
LARGE_INTESTINE	SLC2A1 →	-2.464	-1.020	<.001	.001	3	4
LARGE_INTESTINE	PARD6B →	-0.825	-0.897	<.001	<.001	3	4
OVARY	TNFRSF21 →	-1.565	-0.951	.002	.005	3	4
LIVER	SAA1 →	-3.252	-1.745	.005	.002	3	4
PANCREAS	DDX60L →	-1.874	-1.279	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006040 vs OGFR — BLOOD_Leukemia

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