Proteoglycan metabolic process

Across TCGA patient cohorts, RNA activity of the Proteoglycan metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCARF2_S856, VIM, and LTBP3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proteoglycan metabolic process activity versus SCARF2_S856 in OV (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SCARF2_S856 →	+1.381	+0.049	.001	.003	3	9
UCEC	VIM →	+0.684	+0.040	<.001	.009	3	9
OV	LTBP3 →	+0.481	+0.042	.001	<.001	3	9
BRCA	RSU1 →	+0.375	+0.023	<.001	<.001	3	8
LUAD	SH3PXD2B →	+0.434	+0.030	<.001	.001	3	8
BRCA	TIMP2 →	+0.591	+0.018	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006029 vs SCARF2_S856 — OV

Explore this scatter interactively →