Proteoglycan metabolic process

Across TCGA patient cohorts, RNA activity of the Proteoglycan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FN1, RFX8, and COL5A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proteoglycan metabolic process activity versus FN1 in OV (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FN1 →	+1.785	+0.200	.002	.003	2	7
OV	RFX8 →	+0.662	+0.177	<.001	.002	3	5
GBM	COL5A1 →	+1.666	+0.213	<.001	.002	3	5
GBM	P4HA2 →	+0.615	+0.194	<.001	<.001	3	5
LSCC	P3H1 →	+0.555	+0.237	<.001	<.001	3	5
CCRCC	GAPLINC →	+0.405	+0.171	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006029 vs FN1 — OV

Explore this scatter interactively →