Proteoglycan metabolic process

Across TCGA cell cohorts, RNA activity of the Proteoglycan metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTNNB1, APOO, and GATM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTNNB1 grouped by Proteoglycan metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CTNNB1 →	-1.235	-0.672	.002	.002	3	5
LUNG_SCLC	APOO →	-0.162	-0.791	<.001	.003	3	5
OVARY	GATM →	-0.144	-0.715	<.001	.004	3	4
OVARY	SLC28A3 →	-0.215	-1.042	<.001	<.001	3	4
BLOOD_Myeloma	SNRPF →	+0.416	+1.193	.001	.005	3	4
BLOOD_Myeloma	GRIN2D →	-0.314	-1.857	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTNNB1 by Proteoglycan metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →