Proteoglycan metabolic process

Across TCGA cell cohorts, RNA activity of the Proteoglycan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STXBP6, GLB1, and LARGE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proteoglycan metabolic process activity versus STXBP6 in LIVER (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	STXBP6 →	+2.140	+0.238	<.001	.001	3	5
OESOPHAGUS	GLB1 →	+0.601	+1.031	.004	.004	2	5
BREAST	LARGE1 →	+2.120	+1.077	.001	.004	3	4
BREAST	COX18 →	+0.929	+1.131	.008	.002	3	4
BREAST	IFI27 →	-3.530	-0.975	.001	.002	3	4
URINARY_TRACT	FBXL17 →	+0.923	+1.256	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006029 vs STXBP6 — LIVER

Explore this scatter interactively →