Aminoglycan catabolic process

Across TCGA patient cohorts, RNA activity of the Aminoglycan catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC11A1, CSF3R, and ADGRG3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aminoglycan catabolic process activity versus SLC11A1 in GBM (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC11A1 →	+1.230	+0.289	<.001	<.001	3	7
GBM	CSF3R →	+0.752	+0.221	<.001	<.001	3	7
GBM	ADGRG3 →	+0.780	+0.252	<.001	<.001	3	7
GBM	VSIG4 →	+1.098	+0.212	<.001	<.001	3	7
GBM	FCGR2A →	+0.743	+0.243	<.001	<.001	3	6
GBM	ADGRE3 →	+0.543	+0.251	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006026 vs SLC11A1 — GBM

Explore this scatter interactively →