Aminoglycan catabolic process

Across TCGA cell cohorts, RNA activity of the Aminoglycan catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEXB, NEU1, and CLIC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aminoglycan catabolic process activity versus HEXB in BLOOD_Leukemia (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HEXB →	+1.110	+0.789	<.001	.004	3	8
LUNG_NSCLC_LUAD	NEU1 →	+0.836	+0.235	.006	.002	3	7
OVARY	CLIC1 →	+0.810	+0.334	.001	.002	3	6
BREAST	HEXA →	+1.421	+0.375	.002	.006	3	6
BONE	ALCAM →	+3.747	+1.917	.002	<.001	3	5
BLOOD_Leukemia	ALDH5A1 →	-1.411	-0.989	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006026 vs HEXB — BLOOD_Leukemia

Explore this scatter interactively →