Aminoglycan biosynthetic process

Across TCGA patient cohorts, RNA activity of the Aminoglycan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPRG1-AS1, MIR601, and FTH1P7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aminoglycan biosynthetic process activity versus TPRG1-AS1 in OV (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TPRG1-AS1 →	-1.068	-0.269	<.001	.002	3	4
HNSC	MIR601 →	-0.902	-0.705	.003	.001	3	4
BRCA	FTH1P7 →	+0.989	+0.617	<.001	<.001	3	4
BRCA	VDAC2P2 →	-0.087	-0.471	.001	.003	3	4
PDAC	PRELID3BP4 →	-0.448	-0.330	.006	<.001	3	4
GBM	PPP2R5CP →	+0.332	+0.557	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006023 vs TPRG1-AS1 — OV

Explore this scatter interactively →