Aminoglycan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Aminoglycan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERF1B, MATN2, and SART3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SERF1B grouped by Aminoglycan biosynthetic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SERF1B →	+0.871	+1.204	.001	.005	3	5
SKIN	MATN2 →	-1.912	-0.828	<.001	.003	3	5
BONE	SART3 →	+0.980	+1.725	.006	.002	3	4
CNS	CRMP1 →	+1.242	+0.837	.007	.003	3	4
LUNG_NSCLC_LUSC	TLCD4 →	-1.120	-1.116	.004	.002	3	4
LUNG_SCLC	SLC25A51 →	+0.587	+1.162	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SERF1B by Aminoglycan biosynthetic process activity — LUNG_SCLC

Explore this box plot interactively →