Aminoglycan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Aminoglycan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEDD9, CRACD, and PTGES, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aminoglycan biosynthetic process activity versus NEDD9 in BLOOD_Myeloma (Pearson r = -0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	NEDD9 →	-2.753	-0.268	<.001	<.001	3	4
SKIN	CRACD →	+1.167	+0.211	.004	.002	3	4
LARGE_INTESTINE	PTGES →	-2.486	-0.530	.002	.009	3	4
SKIN	KRT80 →	-2.426	-0.255	.004	.003	3	4
LUNG_NSCLC_LUAD	UGDH →	+1.716	+0.352	<.001	<.001	3	4
CNS	ADPRH →	-1.328	-0.305	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006023 vs NEDD9 — BLOOD_Myeloma

Explore this scatter interactively →