Aminoglycan metabolic process

Across TCGA patient cohorts, RNA activity of the Aminoglycan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HJURP, KIF11, and EME1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aminoglycan metabolic process activity versus HJURP in UCEC (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HJURP →	-0.701	-0.154	.003	.007	3	5
UCEC	KIF11 →	-0.705	-0.180	<.001	.001	3	5
BRCA	EME1 →	-0.407	-0.103	.006	.004	3	5
UCEC	TPX2 →	-0.988	-0.176	.001	.002	3	5
GBM	LOXL2 →	+0.820	+0.254	<.001	<.001	3	5
GBM	IFITM2 →	+0.566	+0.182	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006022 vs HJURP — UCEC

Explore this scatter interactively →