Aminoglycan metabolic process

Across TCGA cell cohorts, RNA activity of the Aminoglycan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRAS2, NR2F2, and CSNK2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RRAS2 grouped by Aminoglycan metabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RRAS2 →	-1.180	-1.054	.001	.003	3	4
LUNG_NSCLC_LUSC	NR2F2 →	-2.295	-1.754	.003	<.001	3	4
LUNG_NSCLC_LUSC	CSNK2B →	-0.606	-1.444	.001	<.001	3	4
CNS	HYI →	-1.154	-0.667	<.001	.005	3	4
CNS	WDR46 →	-0.449	-0.862	.002	<.001	3	4
SKIN	CDC5L →	-0.343	-0.984	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RRAS2 by Aminoglycan metabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →