Aminoglycan metabolic process

Across TCGA cell cohorts, RNA activity of the Aminoglycan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRK, ATF1, and ATP6V0D1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aminoglycan metabolic process activity versus SNRK in BLOOD_Myeloma (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SNRK →	+1.213	+0.290	.001	.003	3	5
BLOOD_Myeloma	ATF1 →	+0.503	+0.277	.001	.006	3	5
BLOOD_Myeloma	ATP6V0D1 →	+0.675	+0.328	.002	<.001	3	5
OVARY	UGDH →	+1.964	+0.494	<.001	<.001	3	5
KIDNEY	NEK10 →	+0.710	+0.287	.003	.002	3	4
URINARY_TRACT	CILK1 →	+1.255	+0.365	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006022 vs SNRK — BLOOD_Myeloma

Explore this scatter interactively →