Inositol metabolic process

Across TCGA patient cohorts, RNA activity of the Inositol metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRBP1, HDLBP, and HSP90B1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inositol metabolic process activity versus RRBP1 in CCRCC (Pearson r = -0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RRBP1 →	-0.473	-0.076	<.001	<.001	3	6
PDAC	HDLBP →	-0.224	-0.049	<.001	.005	3	5
CCRCC	HSP90B1 →	-0.475	-0.079	<.001	<.001	3	5
CCRCC	HSPA5 →	-0.247	-0.053	<.001	<.001	3	5
CCRCC	P4HB →	-0.317	-0.050	<.001	<.001	3	5
PDAC	PPIP5K1 →	+0.382	+0.072	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006020 vs RRBP1 — CCRCC

Explore this scatter interactively →