Inositol metabolic process

Across TCGA patient cohorts, RNA activity of the Inositol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATF7, RNY4P10, and RPS29P7, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inositol metabolic process activity versus ATF7 in HNSC (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ATF7 →	-0.561	-0.468	.009	.008	3	3
HNSC	RNY4P10 →	-0.791	-0.602	.007	.002	3	3
HNSC	RPS29P7 →	-0.876	-0.626	.001	<.001	3	3
HNSC	NOTCH3 →	-0.495	-0.480	.005	<.001	3	3
GBM	TNS1-AS1 →	-0.743	-0.330	<.001	<.001	3	3
LSCC	WWTR1-IT1 →	-0.796	-0.414	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006020 vs ATF7 — HNSC

Explore this scatter interactively →