Inositol metabolic process

Across TCGA cell cohorts, RNA activity of the Inositol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNASEH2A, C8orf37, and KTN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inositol metabolic process activity versus RNASEH2A in STOMACH (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RNASEH2A →	+1.949	+1.712	.001	<.001	3	6
BLOOD_Myeloma	C8orf37 →	+0.815	+1.267	<.001	<.001	3	5
LUNG_NSCLC_LUAD	KTN1 →	+0.635	+0.993	.003	.003	3	4
LIVER	MOB1B →	+1.153	+1.915	<.001	<.001	3	4
STOMACH	NUDT1 →	+1.984	+1.515	.001	.001	3	4
STOMACH	SPC24 →	+2.218	+1.483	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006020 vs RNASEH2A — STOMACH

Explore this scatter interactively →