UDP-glucose metabolic process

Across TCGA patient cohorts, RNA activity of the UDP-glucose metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ENTPD5, GALT, and ADAM10_T719, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UDP-glucose metabolic process activity versus ENTPD5 in GBM (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ENTPD5 →	+0.327	+0.050	.004	.001	3	7
HNSC	GALT →	+0.352	+0.057	<.001	<.001	3	5
CCRCC	ADAM10_T719 →	-0.406	-0.034	.004	<.001	3	4
PDAC	HUWE1_S1395 →	+0.314	+0.034	<.001	<.001	3	4
COAD	PVR →	+0.214	+0.026	.001	<.001	3	4
BRCA	SYDE2_S622 →	+0.910	+0.047	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006011 vs ENTPD5 — GBM

Explore this scatter interactively →