UDP-glucose metabolic process

Across TCGA patient cohorts, RNA activity of the UDP-glucose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HJURP, NUF2, and CDC6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UDP-glucose metabolic process activity versus HJURP in UCEC (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HJURP →	-0.611	-0.118	.002	.002	3	5
LSCC	NUF2 →	-0.667	-0.136	<.001	<.001	3	5
LSCC	CDC6 →	-0.620	-0.131	.001	.005	3	5
UCEC	POLQ →	-0.544	-0.125	.009	.001	2	6
LSCC	KIF18B →	-0.532	-0.130	.002	<.001	3	4
CCRCC	CRHR2 →	-0.284	-0.129	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006011 vs HJURP — UCEC

Explore this scatter interactively →