UDP-glucose metabolic process

Across TCGA cell cohorts, RNA activity of the UDP-glucose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM14, CMAS, and TRIM24, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIM14 grouped by UDP-glucose metabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TRIM14 →	+1.082	+1.409	.002	<.001	3	3
LUNG_NSCLC_LUAD	CMAS →	+0.771	+0.868	<.001	.005	3	3
BONE	TRIM24 →	-0.992	-0.567	.003	.004	3	3
PANCREAS	TRAF1 →	-1.203	-1.844	.001	<.001	3	3
KIDNEY	BAHD1 →	-0.719	-0.965	.001	.001	3	3
KIDNEY	ANXA2R →	+1.341	+0.896	.007	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIM14 by UDP-glucose metabolic process activity — OESOPHAGUS

Explore this box plot interactively →