UDP-glucose metabolic process

Across TCGA cell cohorts, RNA activity of the UDP-glucose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ONECUT2, MDM2, and MUC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UDP-glucose metabolic process activity versus ONECUT2 in STOMACH (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ONECUT2 →	-2.112	-0.310	.004	.003	3	4
STOMACH	MDM2 →	+1.498	+0.260	.005	.006	3	4
LUNG_SCLC	MUC1 →	+2.316	+0.279	.005	.001	3	4
SKIN	SLC12A7 →	-2.355	-0.239	.002	.009	3	3
SKIN	CDX1 →	+0.039	+0.281	.001	.008	3	3
BONE	HECW2 →	+1.180	+0.311	<.001	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006011 vs ONECUT2 — STOMACH

Explore this scatter interactively →