Glucose catabolic process

Across TCGA patient cohorts, RNA activity of the Glucose catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ICAM1, HK3, and TP53, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucose catabolic process activity versus ICAM1 in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ICAM1 →	+0.549	+0.029	<.001	<.001	3	7
BRCA	HK3 →	+0.523	+0.036	<.001	.001	3	6
BRCA	TP53 →	+1.110	+0.046	<.001	<.001	3	6
BRCA	GLIPR2 →	+0.476	+0.047	.001	<.001	3	5
COAD	ALOX5 →	+0.301	+0.033	.006	<.001	3	5
PDAC	AP3B1 →	-0.130	-0.031	.003	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006007 vs ICAM1 — BRCA

Explore this scatter interactively →