Glucose catabolic process

Across TCGA patient cohorts, RNA activity of the Glucose catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NGDN, EGLN3, and HILPDA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucose catabolic process activity versus NGDN in CCRCC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NGDN →	+0.285	+0.129	.001	.005	3	4
PDAC	EGLN3 →	+0.969	+0.177	<.001	<.001	3	4
CCRCC	HILPDA →	+0.900	+0.136	<.001	<.001	3	4
LUAD	ADM →	+1.052	+0.174	<.001	<.001	3	4
CCRCC	CFAP221 →	-0.616	-0.154	.007	.001	3	4
CCRCC	STRN3 →	+0.254	+0.136	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006007 vs NGDN — CCRCC

Explore this scatter interactively →