Glucose catabolic process

Across TCGA cell cohorts, RNA activity of the Glucose catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLCN7, CBX4, and TRMT12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLCN7 grouped by Glucose catabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CLCN7 →	-1.243	-0.325	<.001	.006	3	5
LUNG_NSCLC_LUSC	CBX4 →	-0.806	-0.465	.002	.004	2	6
LUNG_NSCLC_LUSC	TRMT12 →	-0.818	-0.390	.002	.001	3	5
URINARY_TRACT	EEF1AKNMT →	-0.723	-0.325	.001	.006	2	5
SKIN	GNPTG →	-0.787	-0.284	<.001	.001	3	4
SOFT_TISSUE	TAS2R31 →	+0.215	+0.257	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLCN7 by Glucose catabolic process activity — URINARY_TRACT

Explore this box plot interactively →