Glucose catabolic process

Across TCGA cell cohorts, RNA activity of the Glucose catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPI, FGD6, and ENO2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucose catabolic process activity versus GPI in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GPI →	+0.883	+0.388	.002	<.001	3	7
LARGE_INTESTINE	FGD6 →	-1.484	-0.247	<.001	.002	3	5
LUNG_SCLC	ENO2 →	+2.394	+0.235	<.001	<.001	3	5
LUNG_NSCLC_LUAD	ABCC3 →	+1.840	+0.171	.002	.007	3	5
LUNG_NSCLC_LUAD	MFF →	+0.971	+0.197	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ATP6V0E2 →	+1.688	+0.395	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006007 vs GPI — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →