Glucose metabolic process

Across TCGA patient cohorts, RNA activity of the Glucose metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS5, TIMP2, and EFEMP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucose metabolic process activity versus RPS5 in HNSC (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPS5 →	-0.163	-0.049	.001	<.001	3	6
BRCA	TIMP2 →	+0.540	+0.020	<.001	<.001	3	6
BRCA	EFEMP2 →	+0.560	+0.024	<.001	<.001	3	6
GBM	RPL10A →	-0.184	-0.028	<.001	.006	2	7
BRCA	NOP56 →	-0.341	-0.025	<.001	<.001	3	6
OV	RPL5 →	-0.208	-0.033	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006006 vs RPS5 — HNSC

Explore this scatter interactively →