Glucose metabolic process

Across TCGA cell cohorts, RNA activity of the Glucose metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNJ11, CAVIN3, and H2BU1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNJ11 grouped by Glucose metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KCNJ11 →	-0.111	-0.121	.008	.004	3	5
PANCREAS	CAVIN3 →	-0.149	-0.146	.002	<.001	2	5
LUNG_SCLC	H2BU1 →	-0.185	-0.146	.008	.003	3	4
OESOPHAGUS	DNAH11 →	-0.133	-0.197	.004	<.001	3	4
BREAST	TRIM62 →	-0.117	-0.161	<.001	<.001	3	4
BREAST	ACACB →	-0.155	-0.124	.009	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNJ11 by Glucose metabolic process activity — BREAST

Explore this box plot interactively →