Glucose metabolic process

Across TCGA cell cohorts, RNA activity of the Glucose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D24, ZC3H7B, and ARFGAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBC1D24 grouped by Glucose metabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TBC1D24 →	-0.811	-0.208	.003	.007	3	4
UPPER_AERODIGESTIVE_TRACT	ZC3H7B →	-0.947	-0.206	.003	.007	3	4
BONE	ARFGAP1 →	-1.058	-0.425	<.001	.002	3	4
BONE	PHLDB1 →	-1.814	-0.451	.002	.002	3	4
PANCREAS	NUDT14 →	-0.812	-0.350	<.001	.009	3	4
STOMACH	AMPD2 →	-0.972	-0.265	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBC1D24 by Glucose metabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →