Fucose metabolic process

Across TCGA patient cohorts, RNA activity of the Fucose metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRPM4_S728, CCDC88B, and PTPN6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fucose metabolic process activity versus TRPM4_S728 in LSCC (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRPM4_S728 →	+0.772	+0.059	.001	.003	3	4
LSCC	CCDC88B →	-0.360	-0.050	<.001	.004	3	4
LSCC	PTPN6 →	-0.192	-0.032	.008	.005	3	4
LSCC	RAC2 →	-0.443	-0.043	<.001	.001	3	4
OV	ST14 →	+0.485	+0.040	<.001	<.001	3	4
COAD	HLA-DMA →	-0.866	-0.038	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006004 vs TRPM4_S728 — LSCC

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