Fucose metabolic process

Across TCGA patient cohorts, RNA activity of the Fucose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRSS30P, PPIAP67, and RFX8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fucose metabolic process activity versus PRSS30P in OV (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PRSS30P →	+0.794	+0.143	.001	<.001	3	4
UCEC	PPIAP67 →	-0.500	-0.182	.005	.001	3	3
OV	RFX8 →	+0.579	+0.124	.007	.004	3	3
UCEC	PLPP4 →	+0.607	+0.186	.008	.001	3	3
UCEC	HSPA1A →	+1.208	+0.203	<.001	<.001	3	3
BRCA	VIPR1 →	+0.801	+0.114	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006004 vs PRSS30P — OV

Explore this scatter interactively →