Fucose metabolic process

Across TCGA cell cohorts, RNA activity of the Fucose metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEIS2, AKT2, and NUDT10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MEIS2 grouped by Fucose metabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MEIS2 →	+0.158	+0.168	<.001	<.001	3	4
OVARY	AKT2 →	+0.151	+0.084	.009	.007	3	4
BLOOD_Myeloma	NUDT10 →	+0.218	+0.120	.007	.007	3	4
LUNG_SCLC	NFKB2 →	+0.242	+0.256	<.001	<.001	3	3
BLOOD_Myeloma	LINC01529 →	+0.275	+0.142	<.001	<.001	3	3
KIDNEY	BMP2 →	-0.166	-0.181	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MEIS2 by Fucose metabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →