Fucose metabolic process

Across TCGA cell cohorts, RNA activity of the Fucose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX41, MALSU1, and THUMPD3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fucose metabolic process activity versus DDX41 in LARGE_INTESTINE (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DDX41 →	-0.755	-1.120	<.001	.001	3	3
OVARY	MALSU1 →	-1.207	-1.937	.006	<.001	3	3
PANCREAS	THUMPD3 →	-0.846	-1.428	.002	.001	3	3
LARGE_INTESTINE	FAM221B →	+0.181	+1.476	.001	<.001	3	3
LUNG_NSCLC_LUAD	SNW1 →	+0.554	+1.075	.002	.001	3	3
LUNG_NSCLC_LUAD	RPL23 →	-0.836	-1.382	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006004 vs DDX41 — LARGE_INTESTINE

Explore this scatter interactively →