"Fructose 2,6-bisphosphate metabolic process"

Across TCGA patient cohorts, RNA activity of the "Fructose 2,6-bisphosphate metabolic process" pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PFKFB2, HDGFL3, and SLC2A1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Fructose 2,6-bisphosphate metabolic process" activity versus PFKFB2 in BRCA (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PFKFB2 →	+0.481	+0.050	<.001	<.001	3	9
GBM	HDGFL3 →	-0.402	-0.071	<.001	<.001	3	8
LSCC	SLC2A1 →	+0.716	+0.083	<.001	<.001	3	7
GBM	HK2 →	+0.577	+0.083	<.001	<.001	3	7
UCEC	PFKFB3 →	+0.405	+0.077	.003	.003	3	6
LSCC	SCLY →	-0.374	-0.086	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006003 vs PFKFB2 — BRCA

Explore this scatter interactively →