Fructose 6-phosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Fructose 6-phosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XRCC1, HCK, and IL4I1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fructose 6-phosphate metabolic process activity versus XRCC1 in LSCC (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	XRCC1 →	-0.368	-0.086	<.001	<.001	3	6
GBM	HCK →	+0.596	+0.085	.001	.001	3	6
LUAD	IL4I1 →	+0.573	+0.071	<.001	.001	3	6
GBM	APOC1 →	+0.670	+0.076	<.001	<.001	3	6
GBM	ALOX5 →	+0.685	+0.084	<.001	.001	3	6
UCEC	FBP1 →	+0.609	+0.087	.009	.007	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006002 vs XRCC1 — LSCC

Explore this scatter interactively →