Fructose 6-phosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Fructose 6-phosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLX, MS4A4A, and GFPT2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fructose 6-phosphate metabolic process activity versus HLX in PDAC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HLX →	+0.375	+0.171	.001	.005	3	8
COAD	MS4A4A →	+0.864	+0.198	.002	<.001	3	7
HNSC	GFPT2 →	+0.988	+0.213	<.001	<.001	3	7
OV	FCGR2A →	+1.109	+0.292	<.001	<.001	3	7
GBM	ERMN →	+1.563	+0.868	.001	.002	3	7
COAD	VIM →	+0.605	+0.137	.004	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006002 vs HLX — PDAC

Explore this scatter interactively →