Fructose 6-phosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Fructose 6-phosphate metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HK2, TALDO1, and GFPT2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HK2 grouped by Fructose 6-phosphate metabolic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	HK2 →	-0.312	-1.615	.008	.001	3	9
SOFT_TISSUE	TALDO1 →	-0.242	-1.020	.007	.005	2	9
BLOOD_Leukemia	GFPT2 →	-0.190	-1.182	.009	.002	2	8
LIVER	HK1 →	-0.262	-1.115	<.001	.005	3	6
BONE	STK40 →	-0.270	-1.331	.007	.006	3	4
SOFT_TISSUE	POU5F1P4 →	+0.350	+1.839	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HK2 by Fructose 6-phosphate metabolic process activity — BLOOD_Myeloma

Explore this box plot interactively →