Fructose 6-phosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Fructose 6-phosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLRX, UGDH, and STK32C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fructose 6-phosphate metabolic process activity versus GLRX in LUNG_NSCLC_LUSC (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GLRX →	+2.986	+0.558	.002	<.001	3	5
LUNG_NSCLC_LUAD	UGDH →	+1.392	+0.242	.009	<.001	3	5
LUNG_NSCLC_LUAD	STK32C →	+0.678	+0.190	.004	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	HIBADH →	+1.095	+0.215	<.001	<.001	3	5
BLOOD_Leukemia	DLD →	+0.747	+0.184	.001	<.001	3	4
LUNG_NSCLC_LUAD	ZNF671 →	-0.847	-0.230	.009	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006002 vs GLRX — LUNG_NSCLC_LUSC

Explore this scatter interactively →