Fructose metabolic process

Across TCGA patient cohorts, RNA activity of the Fructose metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBM47, PRAM1_S484, and AKR7A3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fructose metabolic process activity versus RBM47 in GBM (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RBM47 →	+0.375	+0.042	.005	<.001	3	6
OV	PRAM1_S484 →	+0.511	+0.033	.004	<.001	3	5
LUAD	AKR7A3 →	+1.141	+0.038	.003	.001	3	5
LUAD	OLFM4 →	+1.051	+0.047	.001	<.001	3	5
OV	APOBR_T572 →	+0.475	+0.034	.004	.002	3	4
PDAC	SP4_S46 →	-0.530	-0.054	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006000 vs RBM47 — GBM

Explore this scatter interactively →