Fructose metabolic process

Across TCGA patient cohorts, RNA activity of the Fructose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PFKFB2, HNRNPA1P10, and PEBP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fructose metabolic process activity versus PFKFB2 in UCEC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PFKFB2 →	+0.887	+0.192	.001	.001	3	6
UCEC	HNRNPA1P10 →	-0.817	-0.162	.009	.005	3	5
CCRCC	PEBP4 →	+0.333	+0.089	.004	.004	3	4
UCEC	ALDH9A1 →	+0.527	+0.153	.005	<.001	3	4
UCEC	SERHL2 →	-0.502	-0.187	.003	<.001	3	4
GBM	CEP72 →	-0.532	-0.239	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006000 vs PFKFB2 — UCEC

Explore this scatter interactively →